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As you lose weight, the body is designed to defend that body weight

For more information, the Alzheimers Associations educational overview on GLP1s captures the balanced state of the science as of late 2025

The drug can cross the blood-brain barrier (BBB) and activate GLP-1R in the CNS [49, 50], thus producing neuroprotective and anti-inflammatory effects [50,51,52,53,54,55]

Wegovy ~16.9% average body weight loss Boosts metabolic & cardiovascular health Proven, long-established safety profile Weekly injection, easy to use Key Takeaways: Wegovy, Cannabis and Safety Clinical evidence currently suggests no confirmed direct pharmacological interaction between Wegovy for weight loss and cannabis